Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas
Nature Communications
Jianxing Yin#, Xiefeng Wang#, XinGe#, Fangshu Ding, Zhumei Shi, Zehe Ge, Guang Huang, Ningwei Zhao, Dongyin Chen, Junxia Zhang, Sam eer Agnihotri, Yuandong Cao, Jing Ji, Fan Lin, QianghuWang , Qigang Zhou, XiuxingWang, Yongping You*, Zhimin Lu* & Xu Qian*
2023-10-05
PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma
Cancer Research
Mengjie Zhao#, Yanhui Li#, Chenfei Lu#, Fangshu Ding, Miao Xu, Xin Ge, Mengdie Li, Zhen Wang, Jianxing Yin, Junxia Zhang, Xiefeng Wang, Zehe Ge, Hong Xiao, Yong Xiao, Hongyi Liu, Wentao Liu, Yuandong Cao, Qianghu Wang, Yongping You, Xiuxing Wang, Kun Yang, Zhumei Shi, Xu Qian*
2023-04-04
Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas
Molecular Cell
Zhumei Shi#, Xin Ge#, Mengdie Li, Jianxing Yin, Xiefeng Wang, Junxia Zhang, Dongyin Chen, Xinjian Li, Xiuxing Wang, Jing Ji, Yongping You*, Xu Qian*
2022-12-01
Diallyl trisulfide sensitizes radiation therapy on glioblastoma through directly targeting thioredoxin 1
Free Radical Biology and Medicine
Yangyang Tian#, Zehe Ge#, Miao Xu#, Xin Ge, Mengjie Zhao, Fangshu Ding, Jianxing Yin, Xiuxing Wang, Yongping You, Zhumei Shi*, Xu Qian*
2022-08-08
PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1
Molecular Cell
Xu Qian*, Xinjian Li, Zhumei Shi, Yan Xia, Qingsong Cai, Daqian Xu, Lin Tan, Linyong Du, Yanhua Zheng, Dan Zhao, Chuanbao Zhang, Philip L Lorenzi, Yongping You, Bing-Hua Jiang, Tao Jiang, Haitao Li, Zhimin Lu*
2019-11-07
文章注释: # 共同一作; * 通讯作者
Stress granules restrain ferroptosis by sequestering ferritin
Nature Cell Biology
Zehe Ge#, Zihan Wang#, Erjie Zhao#, Yizhuo Guo#, Longxiu Zhang, Fuwei Tian, Mengdie Li, Yunfei Ma, Fangshu Ding, Liuguijie He, Shuhong Sun, Minfeng Tong, Wenxia Xu, Xiefeng Wang, Junxia Zhang, Lingxiang Wu, Yudan Zhang, Lili Niu, Qianghu Wang, Rong Yin, Xiao Li, Yongping You, Jeremy N. Rich, Xiuxing Wang, Bing Yao, Zhumei Shi*, Zhou Yang*, Xin Ge*, Fang Liu*, Bo Chu*, Xu Qian*
2026-03-03
Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation
Cell Reports
Zehe Ge, Miao Xu, Yuqian Ge, Guang Huang, Dongyin Chen, Xiuquan Ye, Yibei Xiao, Hongyu Zhu, Rong Yin, Hua Shen, Gaoxiang Ma, Lianwen Qi, Guining Wei, Dongmei Li, Shaofeng Wei, Meng Zhu, Hongxia Ma, Zhumei Shi, Xiuxing Wang, Xin Ge, Xu Qian*
2023-11-28
Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly
Science Translational Medicine
Jianxing Yin#, Xin Ge#, Fangshu Ding#, Liuguijie He, Keying Song, Zhumei Shi, Zehe Ge, Junxia Zhang, Jing Ji, Xiefeng Wang, Ningwei Zhao, Chuanjun Shu, Fan Lin, Qianghu Wang, Qigang Zhou, Yuandong Cao, Wentao Liu, Dan Ye, Jeremy N Rich, Xiuxing Wang*, Yongping You*, Xu Qian*
2024-03-22
Chromium (VI)-induced ALDH1A1/EGF axis promotes lung cancer progression
Clinical and Translational Medicine
Xin Ge#, Mengdie Li#, Guo-Xin Song#, Zhixiang Zhang, Jianxing Yin, Zehe Ge, Zhumei Shi, Ling-Zhi Liu, Bing-Hua Jiang*, Xu Qian*, Hua Shen*
2022-12
Programmable base editing of mutated TERT promoter inhibits brain tumour growth
Nature Cell Biology
Xinjian Li#, Xu Qian#, Bin Wang, Yan Xia, Yanhua Zheng, Linyong Du, Daqian Xu, Dongming Xing, R. DePinho*, Zhimin Lu*
2020-02-17
KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis
Molecular Cell
Xu Qian*, Xinjian Li, Zhumei Shi, Xiaoming Bai, Yan Xia, Yanhua Zheng, Daqian Xu, Feng Chen, Yongping You, Jing Fang, Zhibin Hu, Qin Zhou, Zhimin Lu*
2019-12-19
Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
Molecular Cell
Xin Ge#, Mengdie Li#, Jianxing Yin, Zhumei Shi, Yao Fu, Ningwei Zhao, Hongshan Chen, Longxiyu Meng, Xinjian Li, Zhibin Hu, Xiaozhi Zhao*, Hongqian Guo*, Xu Qian*
2022-02-04
